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Megestol Oral Suspension 100ml
Megestrol Acetate 200 mg/5 ml is used in the treatment of Breast cancer and endometrial cancer.
- Hormonal Action: Megestrol interferes with the hormones responsible for cancer growth.
- Cancer Progression Control: Reducing the influence of these hormones, slows the growth of cancer cells and alleviates associated symptoms.
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✅ Description:
Safety Advices
Alcohol
UNSAFE
Avoid alcohol to reduce the risk of side effects.
Pregnancy
UNSAFE
Megestol Oral Suspension is generally not recommended for use during pregnancy and in women planning for pregnancy. Consult your doctor before taking the medicine.
Breastfeeding
UNSAFE
Megestol Oral Suspension is not generally recommended for use in breastfeeding women. Consult your doctor before taking the medicine
Driving
CAUTION
Megestol Oral Suspension is unlikely to affect your ability to drive, but consult your doctor if you feel unwell.
Kidney
CONSULT YOUR DOCTOR
Megestol should be used with caution in patients with kidney problems such as chronic kidney disease. Consult your doctor before taking Megestol.
Liver
CONSULT YOUR DOCTOR
Megestol should be used with caution in patients with severe liver problems. Consult your doctor before taking Megestol.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Megestol Oral Suspension
- Breast Cancer:
- Helps manage symptoms like lumps, nipple/breast shape changes, and bloody discharge from nipples.
- Endometrial Cancer:
- Addresses pelvic pain, bleeding between periods, and pain during sexual intercourse.
✔️ How does Megestol Oral Suspension work?
It acts by interfering with the production of hormones that cause cancer's development. It helps to reduce cancer symptoms effectively. It can also be used to treat loss of appetite in patients with HIV/AIDS.
✔️ Most side effects are manageable but consult your doctor if they persist or worsen:
- Increased appetite and weight gain
- Shortness of breath
- Hot flushes (redness on the face and neck)
- High blood pressure
- Increased blood sugar levels
- Rounded face (Cushingoid appearance)
- Constipation
- Swelling of a vein due to a blood clot (thrombophlebitis)
✔️ Antineoplastic Effects in Endometrial Cancer
- Exact Mechanism Unknown: Its antineoplastic effects are not fully understood.
- Gonadotropin Suppression: It inhibits pituitary gonadotropin production, reducing estrogen secretion, which may contribute to its effects against endometrial carcinoma.
✔️ Antineoplastic Effects in Breast Cancer
Modification of Steroid Hormones:
- Alters the actions of steroid hormones.
- Exerts a direct cytotoxic effect on tumor cells.
- Receptor Mechanism:
- In metastatic cancer, tumor cells may or may not have hormone receptors.
- Megestrol Acetate influences the estrogen-receptor mechanism, disrupting the cyclic process of estrogen activity in target cells.
- It prevents estrogen from inducing gene transcription and altering cell functions.
- Reduction of Hormone-Dependent Cancer Cells:
- High pharmacologic doses of Megestrol Acetate decrease hormone-dependent breast cancer cells.
- It blocks or abolishes the stimulatory effects of estrogen on these cells.
✔️ Pharmacokinetics
Absorption:
- Peak plasma concentrations are reached 2–3 hours after a single oral dose of 160 mg.
Plasma Half-Life:
- The plasma half-life is 33–38 hours, allowing for sustained activity.
Excretion:
- Urine: ~66% of the administered dose is excreted via urine.
- Feces: ~20% of the dose is excreted in feces.
✔️ Dosage & Administration of Megestol Oral Suspension
The recommended adult initial dosage of Megestrol Oral Suspension is 800 mg/day (20 ml/day).
- For Special Populations:
- Elderly: Use with caution.
- Children: Not recommended.
- Pregnant and Breastfeeding Women: Not recommended.
✔️ Interaction
- Megestol Oral Suspension may interact with a medicine used to treat heart rhythm disorders (dofetilide) and an anticoagulant (warfarin).
- Megestol Oral Suspension should be used with caution in patients with severe liver problems, a history of thrombophlebitis (blood clots), stroke, adrenal gland disorder, and diabetes.
✔️ Do Not Use If
- Allergic to Megestrol or any of the tablet's contents.
✔️ Inform Your Doctor If You Have
- Severe liver problems
- History of thrombophlebitis or stroke
- Adrenal gland disorders
- Diabetes
✔️ Safety Information for Megestol Oral Suspension
1. Increased Risk of Blood Clots
- Caution in Thrombophlebitis History: Patients with a history of blood clots or thrombophlebitis should use this medication with caution.
- Signs of Blood Clots: Watch for the following symptoms and inform your doctor immediately:
- Impaired coordination
- Difficulty speaking
- Pain in the groin
- Pain in the arm or leg (especially in the calf)
- Shortness of breath
- General weakness
- Headache or dizziness
2. Pregnancy Precautions
- Not Recommended During Pregnancy: Megestol Oral Suspension is contraindicated in pregnancy due to potential harm to the fetus.
- Contraception: Use a reliable contraceptive method to prevent pregnancy while on this medication.
- Pregnancy Test: You may need to undergo a pregnancy test before starting this medication.
3. Lactose Intolerance
- Contains Lactose: Inform your doctor if you have a known intolerance to sugars, as this medication contains lactose.
✔️ Storage Conditions:
- Keep Megestol Oral Suspension out of reach of children
- Do not store Megestol Oral Suspension above 25°C
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
